Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, and it is responsible for up to one million deaths annually.Although multiple risk factors for HCC have been identified, and despite preventive measures, the incidence of HCC continues to rise to epidemiologic proportions in the United States.In general, tumor resection and o
Abstract In this paper, for every relation R on a vector space V, we consider the R-vector space ( V , R ) $(V,R)$ and define the notions of R-convexity, R-convex hull, and R-extreme point in this space.Some examples are provided to compare them with the reference cases.The effects of some operations on R-convex sets are investigated.In particular,
Many participants in HIV-1 vaccine trials, who have not previously been exposed to or vaccinated against HIV-1, display serum immunoglobulin antibodies that bind the gp41 region of HIV-1 envelope prior to vaccination.Previous studies have hypothesized that these pre-existing antibodies may be cross-reactive and may skew future vaccine responses.In
Oncolytic virotherapy is a rapidly evolving approach that aims to selectively kill cancer cells.We designed a promising recombinant vaccinia virus, VV-GMCSF-Lact, for the treatment of solid tumors, including glioma.We assessed how VV-GMCSF-Lact affects human cells using immortalized and patient-derived glioma cultures and a non-malignant brain cell